Dual IRE1 RNase functions dictate glioblastoma development

Dual IRE1 RNase functions dictate glioblastoma development

Abstract Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical role in cancer development. This concept is valid in glioblastoma mul...

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Bibliographic Details
Main Authors: Stéphanie Lhomond, Tony Avril, Nicolas Dejeans, Konstantinos Voutetakis, Dimitrios Doultsinos, Mari McMahon, Raphaël Pineau, Joanna Obacz, Olga Papadodima, Florence Jouan, Heloise Bourien, Marianthi Logotheti, Gwénaële Jégou, Néstor Pallares‐Lupon, Kathleen Schmit, Pierre‐Jean Le Reste, Amandine Etcheverry, Jean Mosser, Kim Barroso, Elodie Vauléon, Marion Maurel, Afshin Samali, John B Patterson, Olivier Pluquet, Claudio Hetz, Véronique Quillien, Aristotelis Chatziioannou, Eric Chevet
Format: Article
Language:English
Published: Wiley 2018-03-01
Series:EMBO Molecular Medicine
Subjects:
cancer
endoplasmic reticulum
IRE1
regulated IRE1‐dependent decay
XBP1
Online Access:https://doi.org/10.15252/emmm.201707929

Internet

https://doi.org/10.15252/emmm.201707929

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