Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways
Osteoclasts (OCs) play an important role in a variety of lytic bone diseases. New bone protective therapies exploration has been focused on the suppression of OC formation. In this study, we report that daily chemical evodiamine from Chinese prickly ash, a very common sauce used for stewing meats, a...
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doaj-fc9ff95cca40475ea9e9475f385488f82021-04-30T07:11:17ZengElsevierJournal of Functional Foods1756-46462017-10-0137594602Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathwaysLei Jiang0Xiaoying Zhao1Jinjin Pei2Lijuan Mei3Yulei Cui4Shuo Wang5Yun Shao6Xiaoling Zhang7Yanduo Tao8Key Laboratory of Tibetan Medicine Research, Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, PR ChinaUniversity of Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200031, PR China; The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai 200031, PR ChinaKey Laboratory of Tibetan Medicine Research, Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, PR China; Shaanxi Key Laboratory of Bioresources and Biology, Shaanxi University of Technology, Hanzhong 723001, PR ChinaKey Laboratory of Tibetan Medicine Research, Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, PR ChinaKey Laboratory of Tibetan Medicine Research, Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR ChinaKey Laboratory of Tibetan Medicine Research, Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, PR China; University of Chinese Academy of Sciences, Beijing 100039, PR ChinaKey Laboratory of Tibetan Medicine Research, Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, PR ChinaUniversity of Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai 200031, PR China; The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai 200031, PR China; Corresponding authors at: No. 23 Xinning Road, Xining, Qinghai, PR China.Key Laboratory of Tibetan Medicine Research, Northwest Plateau Institute of Biology, Chinese Academy of Sciences, Xining 810001, PR China; Corresponding authors at: No. 23 Xinning Road, Xining, Qinghai, PR China.Osteoclasts (OCs) play an important role in a variety of lytic bone diseases. New bone protective therapies exploration has been focused on the suppression of OC formation. In this study, we report that daily chemical evodiamine from Chinese prickly ash, a very common sauce used for stewing meats, attenuates RANKL-induced OC formation, the expression level of OC-specific marker genes and OC marker protein in vitro. Mechanistically, evodiamine dose- and time-dependently blocked the RANKL-induced activation of ERK and c-Fos as well as the induction of NFATc1, which is essential for OC formation. These data suggest that evodiamine might be a useful alternative therapy in preventing or treating osteolytic diseases.http://www.sciencedirect.com/science/article/pii/S1756464617304309EvodiamineZanthoxylum bungeanumRANKLOsteoclast differentiationERKNFATc1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lei Jiang Xiaoying Zhao Jinjin Pei Lijuan Mei Yulei Cui Shuo Wang Yun Shao Xiaoling Zhang Yanduo Tao |
spellingShingle |
Lei Jiang Xiaoying Zhao Jinjin Pei Lijuan Mei Yulei Cui Shuo Wang Yun Shao Xiaoling Zhang Yanduo Tao Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways Journal of Functional Foods Evodiamine Zanthoxylum bungeanum RANKL Osteoclast differentiation ERK NFATc1 |
author_facet |
Lei Jiang Xiaoying Zhao Jinjin Pei Lijuan Mei Yulei Cui Shuo Wang Yun Shao Xiaoling Zhang Yanduo Tao |
author_sort |
Lei Jiang |
title |
Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways |
title_short |
Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways |
title_full |
Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways |
title_fullStr |
Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways |
title_full_unstemmed |
Daily chemical evodiamine from Chinese prickly ash attenuates osteoclast differentiation through RANKL induced NFAT pathways |
title_sort |
daily chemical evodiamine from chinese prickly ash attenuates osteoclast differentiation through rankl induced nfat pathways |
publisher |
Elsevier |
series |
Journal of Functional Foods |
issn |
1756-4646 |
publishDate |
2017-10-01 |
description |
Osteoclasts (OCs) play an important role in a variety of lytic bone diseases. New bone protective therapies exploration has been focused on the suppression of OC formation. In this study, we report that daily chemical evodiamine from Chinese prickly ash, a very common sauce used for stewing meats, attenuates RANKL-induced OC formation, the expression level of OC-specific marker genes and OC marker protein in vitro. Mechanistically, evodiamine dose- and time-dependently blocked the RANKL-induced activation of ERK and c-Fos as well as the induction of NFATc1, which is essential for OC formation. These data suggest that evodiamine might be a useful alternative therapy in preventing or treating osteolytic diseases. |
topic |
Evodiamine Zanthoxylum bungeanum RANKL Osteoclast differentiation ERK NFATc1 |
url |
http://www.sciencedirect.com/science/article/pii/S1756464617304309 |
work_keys_str_mv |
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