Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ω3- and ω6-long-chain-PUFA deficiency

Novel CB1-ligands maintain homeostasis of the endocannabinoid system in ω3- and ω6-long-chain-PUFA deficiency

Mammalian ω3- and ω6-PUFAs are synthesized from essential fatty acids (EFAs) or supplied by the diet. PUFAs are constitutive elements of membrane architecture and precursors of lipid signaling molecules. EFAs and long-chain (LC)-PUFAs are precursors in the synthesis of endocannabinoid ligands of Gi/...

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Bibliographic Details
Main Authors: Ina Hammels, Erika Binczek, Inga Schmidt-Soltau, Britta Jenke, Andreas Thomas, Matthias Vogel, Mario Thevis, Dilyana Filipova, Symeon Papadopoulos, Wilhelm Stoffel
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Journal of Lipid Research
Subjects:
fatty acid desaturase 2-deficient mouse model
arachidonic acid
diet effects
lipid metabolism
ω3 fatty acids
cannabinoid receptor 1
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322343

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http://www.sciencedirect.com/science/article/pii/S0022227520322343

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