Rational design of a hypoallergenic Phl p 7 variant for immunotherapy of polcalcin-sensitized patients

Rational design of a hypoallergenic Phl p 7 variant for immunotherapy of polcalcin-sensitized patients

Abstract Polcalcins are important respiratory panallergens, whose IgE-binding capacity depends on the presence of calcium. Since specific immunotherapy is not yet available for the treatment of polcalcin-sensitized patients, we aimed to develop a molecule for efficient and safe immunotherapy. We gen...

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Bibliographic Details
Main Authors: Marianne Raith, Doris Zach, Linda Sonnleitner, Konrad Woroszylo, Margarete Focke-Tejkl, Herbert Wank, Thorsten Graf, Annette Kuehn, Mariona Pascal, Rosa Maria Muñoz-Cano, Judith Wortmann, Philipp Aschauer, Walter Keller, Simone Braeuer, Walter Goessler, Ines Swoboda
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-019-44208-0

Internet

https://doi.org/10.1038/s41598-019-44208-0

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