Rational design of a hypoallergenic Phl p 7 variant for immunotherapy of polcalcin-sensitized patients
Abstract Polcalcins are important respiratory panallergens, whose IgE-binding capacity depends on the presence of calcium. Since specific immunotherapy is not yet available for the treatment of polcalcin-sensitized patients, we aimed to develop a molecule for efficient and safe immunotherapy. We gen...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-05-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-019-44208-0 |