The role of ectonucleotidases CD39 and CD73 and adenosine signalling in solid organ transplantation
Extracellular adenosine is a potent immunomodulatory molecule that accumulates in states of inflammation. Nucleotides such as adenosine triphosphate (ATP) and adenosine diphosphate (ADP) are release from injured and necrotic cells and hydrolysed to adenosine monophosphate (AMP) and adenosine by the...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00064/full |