Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase

Homology sensing via non-linear amplification of sequence-dependent pausing by RecQ helicase

RecQ helicases promote genomic stability through their unique ability to suppress illegitimate recombination and resolve recombination intermediates. These DNA structure-specific activities of RecQ helicases are mediated by the helicase-and-RNAseD like C-terminal (HRDC) domain, via unknown mechanism...

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Bibliographic Details
Main Authors: Yeonee Seol, Gábor M Harami, Mihály Kovács, Keir C Neuman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
single molecule biophysics
homologous recombination
unwinding mechanism
magnetic tweezers
genome stability
helicase
Online Access:https://elifesciences.org/articles/45909

Internet

https://elifesciences.org/articles/45909

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