Reversed Senescence of Retinal Pigment Epithelial Cell by Coculture With Embryonic Stem Cell via the TGFβ and PI3K Pathways

Retinal pigment epithelium (RPE) cellular senescence is an important etiology of age-related macular degeneration (AMD). Aging interventions based on the application of stem cells to delay cellular senescence have shown good prospects in the treatment of age-related diseases. This study aimed to inv...

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Bibliographic Details
Main Authors: Shoubi Wang, Yurun Liu, Ying Liu, Chaoyang Li, Qi Wan, Liu Yang, Yaru Su, Yaqi Cheng, Chang Liu, Xiaoran Wang, Zhichong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.588050/full