The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism: Novel Perspectives in Management of Angiogenesis and Cancer Therapy

The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism: Novel Perspectives in Management of Angiogenesis and Cancer Therapy

The activation of endothelial cells (ECs) is a crucial step on the road map of tumor angiogenesis and expanding evidence indicates that a pro-oxidant tumor microenvironment, conditioned by cancer metabolic rewiring, is a relevant controller of this process. Herein, we investigated the contribution o...

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Bibliographic Details
Main Authors: Filipa Lopes-Coelho, Filipa Martins, Ana Hipólito, Cindy Mendes, Catarina O. Sequeira, Rita F. Pires, António M. Almeida, Vasco D. B. Bonifácio, Sofia A. Pereira, Jacinta Serpa
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Oncology
Subjects:
angiogenesis
ferroptosis
oxidative stress
lipid peroxidation
endothelial cell hyperactivation
propranolol
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.656229/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.656229/full

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