Virus subtype-specific suppression of MAVS aggregation and activation by PB1-F2 protein of influenza A (H7N9) virus.

Human infection with avian influenza A (H5N1) and (H7N9) viruses causes severe respiratory diseases. PB1-F2 protein is a critical virulence factor that suppresses early type I interferon response, but the mechanism of its action in relation to high pathogenicity is not well understood. Here we show...

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Bibliographic Details
Main Authors: Pak-Hin Hinson Cheung, Tak-Wang Terence Lee, Chun Kew, Honglin Chen, Kwok-Yung Yuen, Chi-Ping Chan, Dong-Yan Jin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008611