Limited Sampling Modeling for Estimation of Phenotypic Metrics for CYP Enzymes and the ABCB1 Transporter Using a Cocktail Approach

Limited Sampling Modeling for Estimation of Phenotypic Metrics for CYP Enzymes and the ABCB1 Transporter Using a Cocktail Approach

Plasma concentration data points (n = 2,640) from 16 healthy adults were used to develop and validate limited sampling strategies (LSS) for estimation of phenotypic metrics for CYP enzymes and the ABCB1 transporter, using a cocktail of subtherapeutic doses of the selective probes caffeine (CYP1A2),...

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Bibliographic Details
Main Authors: Eduardo Barbosa Coelho, Diego Alberto Ciscato Cusinato, João Paulo Ximenez, Vera Lucia Lanchote, Claudio José Struchiner, Guilherme Suarez-Kurtz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
caffeine
fexofenadine
midazolam
metoprolol
omeprazole
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00022/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00022/full

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