Differential Proteomics Reveals miR-155 as a Novel Indicator of Liver and Spleen Pathology in the Symptomatic Niemann-Pick Disease, Type C1 Mouse Model

Differential Proteomics Reveals miR-155 as a Novel Indicator of Liver and Spleen Pathology in the Symptomatic Niemann-Pick Disease, Type C1 Mouse Model

Niemann-Pick disease, type C1 (NPC1) is a rare, autosomal recessive, lipid storage disorder caused by mutations in NPC1. As a result, there is accumulation of unesterified cholesterol and sphingolipids in the late endosomal/lysosomal system. Clinically, patients can present with splenomegaly and hep...

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Bibliographic Details
Main Authors: Melissa R. Pergande, Antony Cougnoux, Rathnayake A. C. Rathnayake, Forbes D. Porter, Stephanie M. Cologna
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
Niemann-Pick type C1
spleen proteomics
AJS-ESI mass spectrometry
lysosomal storage disorder
miR-155
Online Access:http://www.mdpi.com/1420-3049/24/5/994

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http://www.mdpi.com/1420-3049/24/5/994

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