MutSβ Stimulates Holliday Junction Resolution by the SMX Complex

MutSβ Stimulates Holliday Junction Resolution by the SMX Complex

Summary: MutSα and MutSβ play important roles in DNA mismatch repair and are linked to inheritable cancers and degenerative disorders. Here, we show that MSH2 and MSH3, the two components of MutSβ, bind SLX4 protein, a scaffold for the assembly of the SLX1-SLX4-MUS81-EME1-XPF-ERCC1 (SMX) trinuclease...

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Bibliographic Details
Main Authors: Sarah J. Young, Marie Sebald, Rajvee Shah Punatar, Meghan Larin, Laura Masino, Monica C. Rodrigo-Brenni, Chih-Chao Liang, Stephen C. West
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:Cell Reports
Subjects:
DNA recombination
DNA repair
SLX1-SLX4
MUS81-EME1
SMX trinuclease
Holliday junction
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472031278X

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http://www.sciencedirect.com/science/article/pii/S221112472031278X

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