Alpha2beta1 Integrin (VLA-2) Protects Activated Human Effector T Cells From Methotrexate-Induced Apoptosis

Alpha2beta1 Integrin (VLA-2) Protects Activated Human Effector T Cells From Methotrexate-Induced Apoptosis

β1 integrins are critical for T cell migration, survival and costimulation. The integrin α2β1, which is a receptor for collagen, also named VLA-2, is a major costimulatory pathway of effector T cells and has been implicated in arthritis pathogenesis. Herein, we have examined its ability to promote m...

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Bibliographic Details
Main Authors: Amna Abderrazak, Mohammed-Amine El Azreq, Dalila Naci, Paul R. Fortin, Fawzi Aoudjit
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
α2β1 integrin
collagen
cell adhesion
methotrexate
rheumatoid arthritis
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02269/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02269/full

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