Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function

Structural and Biological Features of FOXP3 Dimerization Relevant to Regulatory T Cell Function

FOXP3 is a key transcription factor for regulatory T cell function. We report the crystal structure of the FOXP3 coiled-coil domain, through which a loose or transient dimeric association is formed and modulated, accounting for the activity variations introduced by disease-causing mutations or post...

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Bibliographic Details
Main Authors: Xiaomin Song, Bin Li, Yan Xiao, Chunxia Chen, Qiang Wang, Yujie Liu, Alan Berezov, Chen Xu, Yayi Gao, Zhiyuan Li, Shiaw-Lin Wu, Zheng Cai, Hongtao Zhang, Barry L. Karger, Wayne W. Hancock, Andrew D. Wells, Zhaocai Zhou, Mark I. Greene
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712001325

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http://www.sciencedirect.com/science/article/pii/S2211124712001325

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