The Third Generation Anti-HER2 Chimeric Antigen Receptor Mouse T Cells Alone or Together With Anti-PD1 Antibody Inhibits the Growth of Mouse Breast Tumor Cells Expressing HER2 in vitro and in Immune Competent Mice

The Third Generation Anti-HER2 Chimeric Antigen Receptor Mouse T Cells Alone or Together With Anti-PD1 Antibody Inhibits the Growth of Mouse Breast Tumor Cells Expressing HER2 in vitro and in Immune Competent Mice

Chimeric Antigen Receptor (CAR)-T cells have great efficacy against CD19+ leukemia but little success for solid tumors. This study explored the effectiveness of third generation anti-HER2 CAR-T cells alone or in combination with anti-PD1 antibody on breast tumor cells expressing HER2 in vitro and in...

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Bibliographic Details
Main Authors: Panyuan Li, Lingcong Yang, Tong Li, Shufang Bin, Bohao Sun, Yuting Huang, Kaiyan Yang, Daming Shan, Haihua Gu, Hongzhi Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Oncology
Subjects:
HER2
breast cancer
chimeric antigen receptor (CAR)-T cells
PD1
immunotherapy
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01143/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.01143/full

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