Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood. Here, we assayed the binding of five essential TFs over multiple stages of embryogenesis in two dist...

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Bibliographic Details
Main Authors: Pierre Khoueiry, Charles Girardot, Lucia Ciglar, Pei-Chen Peng, E Hilary Gustafson, Saurabh Sinha, Eileen EM Furlong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
enhancer
developmental enhancer
evolution
cis-regulatory control
inter-species ChIP
divergence
Online Access:https://elifesciences.org/articles/28440

Internet

https://elifesciences.org/articles/28440

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