Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis

Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis

Abstract The hydroxylase cytochrome P450 1A1 (CYP1A1) is regulated by the inflammation-limiting aryl hydrocarbon receptor (AhR), but CYP1A1 immune functions remain unclear. We observed CYP1A1 overexpression in peritoneal macrophages (PMs) isolated from mice following LPS or heat-killed Escherichia....

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Bibliographic Details
Main Authors: Li-Xing Tian, Xin Tang, Jun-Yu Zhu, Li Luo, Xiao-Yuan Ma, Shao-Wen Cheng, Wei Zhang, Wan-Qi Tang, Wei Ma, Xue Yang, Chuan-Zhu Lv, Hua-Ping Liang
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cell Communication and Signaling
Subjects:
Cytochrome P450 1A1
Inflammation
Phagocytosis
Macrophages
Sepsis
Online Access:http://link.springer.com/article/10.1186/s12964-020-0523-3

Internet

http://link.springer.com/article/10.1186/s12964-020-0523-3

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