Chemically Synthesized <i>Alcaligenes</i> Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of <i>Streptococcus</i> <i>pneumoniae</i>-Specific IgA and Th17 Mediated Protective Immunity

Chemically Synthesized <i>Alcaligenes</i> Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of <i>Streptococcus</i> <i>pneumoniae</i>-Specific IgA and Th17 Mediated Protective Immunity

Effective and safe vaccine adjuvants are needed to appropriately augment mucosal vaccine effects. Our previous study demonstrated that lipopolysaccharide (LPS) from Peyer’s patch resident <i>Alcaligenes</i> stimulated dendritic cells to promote the production of mucosal immunity-enhancin...

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Bibliographic Details
Main Authors: Ken Yoshii, Koji Hosomi, Atsushi Shimoyama, Yunru Wang, Haruki Yamaura, Takahiro Nagatake, Hidehiko Suzuki, Huangwenxian Lan, Hiroshi Kiyono, Koichi Fukase, Jun Kunisawa
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Microorganisms
Subjects:
<i>Alcaligenes</i> lipid A
IgA antibody
neutrophil
pneumococcal surface protein A (PspA), <i>Streptococcus pneumoniae</i>
Th17 response
Online Access:https://www.mdpi.com/2076-2607/8/8/1102

Internet

https://www.mdpi.com/2076-2607/8/8/1102

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