Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats

Koumine Decreases Astrocyte-Mediated Neuroinflammation and Enhances Autophagy, Contributing to Neuropathic Pain From Chronic Constriction Injury in Rats

Koumine, an indole alkaloid, is a major bioactive component of Gelsemium elegans. Previous studies have demonstrated that koumine has noticeable anti-inflammatory and analgesic effects in inflammatory and neuropathic pain (NP) models, but the mechanisms involved are not well understood. This study w...

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Bibliographic Details
Main Authors: Gui-lin Jin, Rong-cai Yue, Sai-di He, Li-mian Hong, Ying Xu, Chang-xi Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Pharmacology
Subjects:
koumine
neuropathic pain
astrocyte
autophagy
apoptosis
rats
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00989/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00989/full

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