Molecular Mechanisms of Leucine Zipper EF-Hand Containing Transmembrane Protein-1 Function in Health and Disease

Molecular Mechanisms of Leucine Zipper EF-Hand Containing Transmembrane Protein-1 Function in Health and Disease

Mitochondrial calcium (Ca2+) uptake shapes cytosolic Ca2+ signals involved in countless cellular processes and more directly regulates numerous mitochondrial functions including ATP production, autophagy and apoptosis. Given the intimate link to both life and death processes, it is imperative that m...

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Bibliographic Details
Main Authors: Qi-Tong Lin, Peter B. Stathopulos
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
leucine zipper
EF-hand
coiled-coil
LETM1
LETM2
calcium signaling
Na+/K+ exchanger
Ca2+/H+ exchanger
structural mechanism
Wolf-Hirschhorn syndrome
cancer
mitochondria
Online Access:http://www.mdpi.com/1422-0067/20/2/286

Internet

http://www.mdpi.com/1422-0067/20/2/286

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