mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).

In non-alcoholic fatty liver disease (NAFLD) and insulin resistance, hepatic de novo lipogenesis is often elevated, but the underlying mechanisms remain poorly understood. Recently, we show that CDK8 functions to suppress de novo lipogenesis. Here, we identify the mammalian target of rapamycin compl...

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Bibliographic Details
Main Authors: Daorong Feng, Dou Yeon Youn, Xiaoping Zhao, Yanguang Gao, William J Quinn, Alus M Xiaoli, Yan Sun, Morris J Birnbaum, Jeffrey E Pessin, Fajun Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4456374?pdf=render

Internet

http://europepmc.org/articles/PMC4456374?pdf=render

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