Partial order optimum likelihood (POOL): maximum likelihood prediction of protein active site residues using 3D Structure and sequence properties.

Partial order optimum likelihood (POOL): maximum likelihood prediction of protein active site residues using 3D Structure and sequence properties.

A new monotonicity-constrained maximum likelihood approach, called Partial Order Optimum Likelihood (POOL), is presented and applied to the problem of functional site prediction in protein 3D structures, an important current challenge in genomics. The input consists of electrostatic and geometric pr...

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Bibliographic Details
Main Authors: Wenxu Tong, Ying Wei, Leonel F Murga, Mary Jo Ondrechen, Ronald J Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC2612599?pdf=render

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http://europepmc.org/articles/PMC2612599?pdf=render

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