High-Efficacy α,β-Dehydromonacolin S Improves Hepatic Steatosis and Suppresses Gluconeogenesis Pathway in High-Fat Diet-Induced Obese Rats

High-Efficacy α,β-Dehydromonacolin S Improves Hepatic Steatosis and Suppresses Gluconeogenesis Pathway in High-Fat Diet-Induced Obese Rats

Isolated α,β-dehydromonacolin S (<i>C5</i>) from soil-derived fungus <i>Aspergillus sclerotiorum</i> PSU-RSPG178 was recently shown to exhibit an inhibitory effect against 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) activity in vitro. In this study, we investigated...

Full description

Bibliographic Details
Main Authors: Jutatip Kaewmalee, Atcharaporn Ontawong, Acharaporn Duangjai, Chittreeya Tansakul, Vatcharin Rukachaisirikul, Chatchai Muanprasat, Chutima Srimaroeng
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
statin
α,β-dehydromonacolin S
lovastatin analog
3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor
hepatic steatosis
type 2 diabetes mellitus
Online Access:https://www.mdpi.com/1424-8247/14/4/375

Internet

https://www.mdpi.com/1424-8247/14/4/375

Similar Items