Modifying splice site usage with ModCon: Maintaining the genetic code while changing the underlying mRNP code

Modifying splice site usage with ModCon: Maintaining the genetic code while changing the underlying mRNP code

Codon degeneracy of amino acid sequences permits an additional “mRNP code” layer underlying the genetic code that is related to RNA processing. In pre-mRNA splicing, splice site usage is determined by both intrinsic strength and sequence context providing RNA binding sites for splicing regulatory pr...

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Bibliographic Details
Main Authors: Johannes Ptok, Lisa Müller, Philipp Niklas Ostermann, Anastasia Ritchie, Alexander T. Dilthey, Stephan Theiss, Heiner Schaal
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
pre-mRNA splicing
Splicing reporter
HEXplorer score
HBond score
Splice donor
Splicing regulatory proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021002142

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http://www.sciencedirect.com/science/article/pii/S2001037021002142

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