Integrating predicted transcriptome from multiple tissues improves association detection.

Integrating predicted transcriptome from multiple tissues improves association detection.

Integration of genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) studies is needed to improve our understanding of the biological mechanisms underlying GWAS hits, and our ability to identify therapeutic targets. Gene-level association methods such as PrediXcan can...

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Bibliographic Details
Main Authors: Alvaro N Barbeira, Milton Pividori, Jiamao Zheng, Heather E Wheeler, Dan L Nicolae, Hae Kyung Im
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007889

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