Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain

Bordetella Pertussis Adenylate Cyclase Toxin Does Not Possess a Phospholipase A Activity; Serine 606 and Aspartate 1079 Residues Are Not Involved in Target Cell Delivery of the Adenylyl Cyclase Enzyme Domain

The adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) plays a crucial role in virulence and airway colonization capacity of the whooping cough agent Bordetella pertussis. The toxin penetrates target cell membranes and exhibits three distinct biological activities. A population of CyaA conform...

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Bibliographic Details
Main Authors: Ladislav Bumba, Jiri Masin, Adriana Osickova, Radim Osicka, Peter Sebo
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Toxins
Subjects:
adenylate cyclase toxin
phospholipase A activity
AC domain translocation
Online Access:http://www.mdpi.com/2072-6651/10/6/245

Internet

http://www.mdpi.com/2072-6651/10/6/245

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