Challenges in detecting and quantifying intron retention from next generation sequencing data

Challenges in detecting and quantifying intron retention from next generation sequencing data

Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the final mRNA. An increasing body of literature has demonstrated a major role for IR in numerous biological functions and in disease. Here we give an overview of the different computational approaches for detect...

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Bibliographic Details
Main Authors: Lucile Broseus, William Ritchie
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Intron retention
mRNA splicing
Bioinformatics
RNA sequencing
Gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037019303721

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http://www.sciencedirect.com/science/article/pii/S2001037019303721

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