A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

Directly modulating the choice between homologous recombination (HR) and non-homologous end joining (NHEJ) - two independent pathways for repairing DNA double-strand breaks (DSBs) - has the potential to improve the efficiency of gene targeting by CRISPR/Cas9. Here, we have developed a rapid and easy...

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Bibliographic Details
Main Authors: Weina Zhang, Yu Chen, Jiaqing Yang, Jing Zhang, Jiayu Yu, Mengting Wang, Xiaodong Zhao, Ke Wei, Xiaoping Wan, Xiaojun Xu, Ying Jiang, Jiayu Chen, Shaorong Gao, Zhiyong Mao
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
CRISPR/Cas9
knock-in
homologous recombination (HR)
non-homologous end joining (NHEJ)
farrerol
Online Access:https://elifesciences.org/articles/56008

Internet

https://elifesciences.org/articles/56008

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