Mild-acid hydrolysis of a native polysulfated fraction from Acanthophora muscoides generates sulfated oligosaccharides displaying in vitro thrombin generation inhibition

Mild-acid hydrolysis of a native polysulfated fraction from Acanthophora muscoides generates sulfated oligosaccharides displaying in vitro thrombin generation inhibition

Acanthophora muscoides (Rhodophyta) has three polysulfated fractions    (Am-1, Am-2 and Am-3). Am-2 displayed anti-inflammation and serpin-independent anticoagulation; however, no effect of oligomers on thrombin-generation (TG) assay has been demonstrated. This study employed mild-acid hydrolysis to...

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Bibliographic Details
Main Authors: José Ariévilo Gurgel Rodrigues, Ismael Nilo Lino de Queiroz, Ana Luíza Gomes Quinderé, Norma Maria Barros Benevides, Ana Maria Freire Tovar, Paulo Antônio de Souza Mourão
Format: Article
Language:English
Published: Universidade Estadual de Maringá 2016-07-01
Series:Acta Scientiarum : Biological Sciences
Subjects:
Rhodophyceae
poli-aniônicos
depolimerização
trombina.
Online Access:http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/28257

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http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/28257

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