Formation of Human Colonic Crypt Array by Application of Chemical Gradients Across a Shaped Epithelial Monolayer

The successful culture of intestinal organoids has greatly enhanced our understanding of intestinal stem cell physiology and enabled the generation of novel intestinal disease models. Although of tremendous value, intestinal organoid culture systems have not yet fully recapitulated the anatomy or ph...

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Bibliographic Details
Main Authors: Yuli Wang, Raehyun Kim, Dulan B. Gunasekara, Mark I. Reed, Matthew DiSalvo, Daniel L. Nguyen, Scott J. Bultman, Christopher E. Sims, Scott T. Magness, Nancy L. Allbritton
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X17301546