A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma[S]

A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma[S]

Niemann-Pick type C1 (NPC1) disease is a rare, progressively fatal neurodegenerative disease for which there are no FDA-approved therapies. A major barrier to developing new therapies for this disorder has been the lack of a sensitive and noninvasive diagnostic test. Recently, we demonstrated that t...

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Bibliographic Details
Main Authors: Xuntian Jiang, Rohini Sidhu, Forbes D. Porter, Nicole M. Yanjanin, Anneliese O. Speak, Danielle Taylor te Vruchte, Frances M. Platt, Hideji Fujiwara, David E. Scherrer, Jessie Zhang, Dennis J. Dietzen, Jean E. Schaffer, Daniel S. Ory
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Journal of Lipid Research
Subjects:
cholesterol
diagnostic tools
liquid chromatography/tandem mass spectrometry
Niemann-Pick disease
oxysterols
neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520370383

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http://www.sciencedirect.com/science/article/pii/S0022227520370383

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