Effective Activation of BK<sub>Ca</sub> Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4<i>H</i>)-one), Known to Be an Opener of KCNQ2/Q3 Channels

Effective Activation of BK<sub>Ca</sub> Channels by QO-40 (5-(Chloromethyl)-3-(Naphthalen-1-yl)-2-(Trifluoromethyl)Pyrazolo [1,5-a]pyrimidin-7(4<i>H</i>)-one), Known to Be an Opener of KCNQ2/Q3 Channels

QO-40 (5-(chloromethyl)-3-(naphthalene-1-yl)-2-(trifluoromethyl) pyrazolo[1,5-a]pyrimidin-7(4<i>H</i>)-one) is a novel and selective activator of KCNQ2/KCNQ3 K<sup>+</sup> channels. However, it remains largely unknown whether this compound can modify any other type of plasmal...

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Bibliographic Details
Main Authors: Wei-Ting Chang, Sheng-Nan Wu
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
OQ-40 (5-(chloromethyl)-3-(naphthalene-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-(4<i>H</i>)-one)
Ca<sup>2+</sup>-activated K<sup>+</sup> current
large-conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channel
single-channel kinetics
hysteresis
Online Access:https://www.mdpi.com/1424-8247/14/5/388

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