Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK

Over-expressed, N-terminally truncated BRAF is detected in the nucleus of cells with nuclear phosphorylated MEK and ERK

BRAF is a cytoplasmic protein kinase, which activates the MEK-ERK signalling pathway. Deregulation of the pathway is associated with the presence of BRAF mutations in human cancer, the most common being V600EBRAF, although structural rearrangements, which remove N-terminal regulatory sequences, have...

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Bibliographic Details
Main Authors: Fiona Hey, Catherine Andreadi, Catherine Noble, Bipin Patel, Hong Jin, Tamihiro Kamata, Kees Straatman, Jinli Luo, Kathryn Balmanno, David T.W. Jones, V. Peter Collins, Simon J. Cook, Christopher J. Caunt, Catrin Pritchard
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Heliyon
Subjects:
Biochemistry
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844018320747

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http://www.sciencedirect.com/science/article/pii/S2405844018320747

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