A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity

A novel nitroalkene vitamin E analogue inhibits the NLRP3 inflammasome and protects against inflammation and glucose intolerance triggered by obesity

Chronic metabolic diseases, like obesity, type II diabetes and atherosclerosis often involve a low-grade and sterile systemic inflammatory state, in which activation of the pro-inflammatory transcription factor NF-kB and the NLRP3 inflammasome play a major role. It is well established that genetic i...

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Bibliographic Details
Main Authors: Rosina Dapueto, Jorge Rodriguez-Duarte, Germán Galliussi, Andrés Kamaid, Mariana Bresque, Carlos Batthyány, Gloria V. López, Carlos Escande
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Redox Biology
Subjects:
Inflammation related diseases
Inflammasomes
Nitroalkenes
Diet induced obesity
Glucose intolerance
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231720310387

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http://www.sciencedirect.com/science/article/pii/S2213231720310387

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