Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain

Retromer, including Vps35, Vps26, and Vps29, is a protein complex responsible for recycling proteins within the endolysosomal pathway. Although implicated in both Parkinson’s and Alzheimer’s disease, our understanding of retromer function in the adult brain remains limited, in part because Vps35 and...

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Bibliographic Details
Main Authors: Hui Ye, Shamsideen A Ojelade, David Li-Kroeger, Zhongyuan Zuo, Liping Wang, Yarong Li, Jessica YJ Gu, Ulrich Tepass, Avital Adah Rodal, Hugo J Bellen, Joshua M Shulman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
VPS29
VPS35
Drosophila
endolysosomal trafficking
TBC1D5
Rab7
Online Access:https://elifesciences.org/articles/51977

Internet

https://elifesciences.org/articles/51977

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