Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies

Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies

Abstract Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the essential proton pump Pma1p, a P-type ATPase, is a potentially effective therapeutic approach that is orthogonal to existing treatme...

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Bibliographic Details
Main Authors: Sabine Ottilie, Gregory M. Goldgof, Andrea L. Cheung, Jennifer L. Walker, Edgar Vigil, Kenneth E. Allen, Yevgeniya Antonova-Koch, Carolyn W. Slayman, Yo Suzuki, Jacob D. Durrant
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Cheminformatics
Subjects:
Antifungal
PMA1
P-type ATPase
Computer modeling
Saccharomyces cerevisiae
In vitro evolution
Online Access:http://link.springer.com/article/10.1186/s13321-018-0261-3

Internet

http://link.springer.com/article/10.1186/s13321-018-0261-3

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