Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies
Abstract Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the essential proton pump Pma1p, a P-type ATPase, is a potentially effective therapeutic approach that is orthogonal to existing treatme...
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BMC
2018-02-01
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| Series: | Journal of Cheminformatics |
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| Online Access: | http://link.springer.com/article/10.1186/s13321-018-0261-3 |
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doaj-fd41685e74f3424eaaeab6152fd0de812020-11-25T00:30:37ZengBMCJournal of Cheminformatics1758-29462018-02-011011910.1186/s13321-018-0261-3Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapiesSabine Ottilie0Gregory M. Goldgof1Andrea L. Cheung2Jennifer L. Walker3Edgar Vigil4Kenneth E. Allen5Yevgeniya Antonova-Koch6Carolyn W. Slayman7Yo Suzuki8Jacob D. Durrant9Division of Host Pathogen Systems and Therapeutics, Department of Pediatrics, School of Medicine, University of California, San DiegoDivision of Host Pathogen Systems and Therapeutics, Department of Pediatrics, School of Medicine, University of California, San DiegoDivision of Host Pathogen Systems and Therapeutics, Department of Pediatrics, School of Medicine, University of California, San DiegoDepartment of Biological Sciences, University of PittsburghDivision of Host Pathogen Systems and Therapeutics, Department of Pediatrics, School of Medicine, University of California, San DiegoDepartment of Genetics, Yale University School of MedicineDivision of Host Pathogen Systems and Therapeutics, Department of Pediatrics, School of Medicine, University of California, San DiegoDepartment of Genetics, Yale University School of MedicineDepartment of Synthetic Biology and Bioenergy, J. Craig Venter InstituteDepartment of Biological Sciences, University of PittsburghAbstract Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the essential proton pump Pma1p, a P-type ATPase, is a potentially effective therapeutic approach that is orthogonal to existing treatments. We identify NSC11668 and hitachimycin as structurally distinct antifungals that inhibit yeast ScPma1p. These compounds provide new opportunities for drug discovery aimed at this important target.http://link.springer.com/article/10.1186/s13321-018-0261-3AntifungalPMA1P-type ATPaseComputer modelingSaccharomyces cerevisiaeIn vitro evolution |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sabine Ottilie Gregory M. Goldgof Andrea L. Cheung Jennifer L. Walker Edgar Vigil Kenneth E. Allen Yevgeniya Antonova-Koch Carolyn W. Slayman Yo Suzuki Jacob D. Durrant |
| spellingShingle |
Sabine Ottilie Gregory M. Goldgof Andrea L. Cheung Jennifer L. Walker Edgar Vigil Kenneth E. Allen Yevgeniya Antonova-Koch Carolyn W. Slayman Yo Suzuki Jacob D. Durrant Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies Journal of Cheminformatics Antifungal PMA1 P-type ATPase Computer modeling Saccharomyces cerevisiae In vitro evolution |
| author_facet |
Sabine Ottilie Gregory M. Goldgof Andrea L. Cheung Jennifer L. Walker Edgar Vigil Kenneth E. Allen Yevgeniya Antonova-Koch Carolyn W. Slayman Yo Suzuki Jacob D. Durrant |
| author_sort |
Sabine Ottilie |
| title |
Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies |
| title_short |
Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies |
| title_full |
Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies |
| title_fullStr |
Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies |
| title_full_unstemmed |
Two inhibitors of yeast plasma membrane ATPase 1 (ScPma1p): toward the development of novel antifungal therapies |
| title_sort |
two inhibitors of yeast plasma membrane atpase 1 (scpma1p): toward the development of novel antifungal therapies |
| publisher |
BMC |
| series |
Journal of Cheminformatics |
| issn |
1758-2946 |
| publishDate |
2018-02-01 |
| description |
Abstract Given that many antifungal medications are susceptible to evolved resistance, there is a need for novel drugs with unique mechanisms of action. Inhibiting the essential proton pump Pma1p, a P-type ATPase, is a potentially effective therapeutic approach that is orthogonal to existing treatments. We identify NSC11668 and hitachimycin as structurally distinct antifungals that inhibit yeast ScPma1p. These compounds provide new opportunities for drug discovery aimed at this important target. |
| topic |
Antifungal PMA1 P-type ATPase Computer modeling Saccharomyces cerevisiae In vitro evolution |
| url |
http://link.springer.com/article/10.1186/s13321-018-0261-3 |
| work_keys_str_mv |
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| _version_ |
1725325903924297728 |