The association of epigenetic clocks in brain tissue with brain pathologies and common aging phenotypes

Epigenetic clocks are calculated by combining DNA methylation states across select CpG sites to estimate biologic age, and have been noted as the most successful markers of biologic aging to date. Yet, limited research has considered epigenetic clocks calculated in brain tissue. We used DNA methylat...

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Bibliographic Details
Main Authors: Francine Grodstein, Bernardo Lemos, Lei Yu, Hans-Ulrich Klein, Artemis Iatrou, Aron S. Buchman, Gemma L. Shireby, Jonathan Mill, Julie A. Schneider, Philip L. De Jager, David A. Bennett
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121001777