Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression

Oral Toxicity of Okadaic Acid in Mice: Study of Lethality, Organ Damage, Distribution and Effects on Detoxifying Gene Expression

In vivo, after administration by gavage to mice and rats, okadaic acid has been reported to produce lesions in liver, small intestine and forestomach. Because several reports differ in the damage detected in different organs, and on okadaic acid distribution after consumption, we determined the toxi...

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Bibliographic Details
Main Authors: Luis M. Botana, Félix V. Vega, Mercedes R. Vieytes, Paz Otero, José Manuel Cifuentes, Roberto Bermúdez, Amparo Alfonso, Henar López-Alonso, Andres C. Vieira, Juan A. Rubiolo
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Toxins
Subjects:
okadaic acid
histopathology
diarrhea
immunohistochemistry
liver
superoxide dismutase 1
catalase
quantitative PCR
mice
Online Access:http://www.mdpi.com/2072-6651/5/11/2093

Internet

http://www.mdpi.com/2072-6651/5/11/2093

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