Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites

Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites

Abstract Background Rodent malaria parasites where the gene encoding circumsporozoite protein (CSP) has been replaced with csp genes from the human malaria parasites, Plasmodium falciparum or Plasmodium vivax, are used as pre-clinical tools to evaluate CSP vaccines in vivo. These chimeric rodent par...

Full description

Bibliographic Details
Main Authors: Catherin Marin-Mogollon, Fiona J. A. van Pul, Shinya Miyazaki, Takashi Imai, Jai Ramesar, Ahmed M. Salman, Beatrice M. F. Winkel, Ahmad Syibli Othman, Hans Kroeze, Severine Chevalley-Maurel, Arturo Reyes-Sandoval, Meta Roestenberg, Blandine Franke-Fayard, Chris J. Janse, Shahid M. Khan
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Malaria Journal
Subjects:
Malaria
P. falciparum
P. vivax
Circumsporozoite protein
CSP
Gene complementation
Online Access:http://link.springer.com/article/10.1186/s12936-018-2431-1

Internet

http://link.springer.com/article/10.1186/s12936-018-2431-1

Similar Items