Drugging a stem cell compartment using Wnt3a protein as a therapeutic.

Drugging a stem cell compartment using Wnt3a protein as a therapeutic.

The therapeutic potential of Wnt proteins has long been recognized but challenges associated with in vivo stability and delivery have hindered their development as drug candidates. By exploiting the hydrophobic nature of the protein we provide evidence that exogenous Wnt3a can be delivered in vivo i...

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Bibliographic Details
Main Authors: Girija R Dhamdhere, Mark Y Fang, Jie Jiang, Katherine Lee, Du Cheng, Rebecca C Olveda, Bo Liu, Kimberley A Mulligan, Jeffery C Carlson, Ryan C Ransom, William I Weis, Jill A Helms
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3882211?pdf=render

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http://europepmc.org/articles/PMC3882211?pdf=render

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