By-Passing Large Screening Experiments Using Sequencing as a Tool to Identify scFv Fragments Targeting Atherosclerotic Lesions in a Novel <em>In Vivo</em> Phage Display Selection

By-Passing Large Screening Experiments Using Sequencing as a Tool to Identify scFv Fragments Targeting Atherosclerotic Lesions in a Novel <em>In Vivo</em> Phage Display Selection

Atherosclerosis is a chronic, progressive inflammatory disease that may develop into vulnerable lesions leading to thrombosis. To interrogate the molecular components involved in this process, single-chain variable fragments (scFvs) from a semi-synthetic human antibody library were selected on the l...

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Bibliographic Details
Main Authors: Pierre Martineau, Gisele Clofent-Sanchez, Jean-Michel Franconi, Pierre Dos Santos, Philippe Massot, Stephane Sanchez, Stephane Bonetto, Jeanny Laroche-Traineau, Kamel Deramchia, Marie-Josee Jacobin-Valat
Format: Article
Language:English
Published: MDPI AG 2012-06-01
Series:International Journal of Molecular Sciences
Subjects:
atherosclerosis
human antibody
single-chain variable fragment (scFv)
semi-synthetic phage display library
<em>in vivo</em> phage display
biopanning
Online Access:http://www.mdpi.com/1422-0067/13/6/6902

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http://www.mdpi.com/1422-0067/13/6/6902

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