The y271 and i274 amino acids in reverse transcriptase of human immunodeficiency virus-1 are critical to protein stability.
Reverse transcriptase (RT) of human immunodeficiency virus (HIV)-1 plays a key role in initiating viral replication and is an important target for developing anti-HIV drugs. Our previous study showed that two mutations (Y271A and I274A) in the turn RT (Gln(269)-Arg(277)) abrogated viral replication,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-07-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2701634?pdf=render |