Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer

Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer

Abstract Background Wnt signaling drives epithelial self-renewal and disease progression in human colonic epithelium and colorectal cancer (CRC). Characterization of Wnt effector pathways is key for our understanding of these processes and for developing therapeutic strategies that aim to preserve t...

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Bibliographic Details
Main Authors: Vanessa Dietinger, Cira R. García de Durango, Svenja Wiechmann, Sophie L. Boos, Marlies Michl, Jens Neumann, Heiko Hermeking, Bernhard Kuster, Peter Jung
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cell Communication and Signaling
Subjects:
O-glycosylation
LARGE2
Wnt signaling
Colorectal cancer
Organoid
Colonic stem cell
Online Access:http://link.springer.com/article/10.1186/s12964-020-00561-6

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http://link.springer.com/article/10.1186/s12964-020-00561-6

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