The E3 Ubiquitin Ligase SCF(Cyclin F) Transmits AKT Signaling to the Cell-Cycle Machinery

The E3 Ubiquitin Ligase SCF(Cyclin F) Transmits AKT Signaling to the Cell-Cycle Machinery

The oncogenic AKT kinase is a key regulator of apoptosis, cell growth, and cell-cycle progression. Despite its important role in proliferation, it remains largely unknown how AKT is mechanistically linked to the cell cycle. We show here that cyclin F, a substrate receptor F-box protein for the SCF (...

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Bibliographic Details
Main Authors: Rajarshi Choudhury, Thomas Bonacci, Xianxi Wang, Andrew Truong, Anthony Arceci, Yanqiong Zhang, Christine A. Mills, Jennifer L. Kernan, Pengda Liu, Michael J. Emanuele
Format: Article
Language:English
Published: Elsevier 2017-09-01
Series:Cell Reports
Subjects:
cell cycle
ubiquitin
phosphorylation
mitogen signaling
AKT
SCF ligase
cyclin F
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717312597

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http://www.sciencedirect.com/science/article/pii/S2211124717312597

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