Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex

Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex

Live-attenuated viral vaccines are highly safe and efficacious but represent complex and often multigenic attenuation mechanisms. Most of these vaccines have been generated empirically by serial passaging of a wild-type (WT) virus in cell culture. One of the safest and most effective live-attenuated...

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Bibliographic Details
Main Authors: Emily H. Davis, Andrew S. Beck, Ashley E. Strother, Jill K. Thompson, Steven G. Widen, Stephen Higgs, Thomas G. Wood, Alan D. T. Barrett
Format: Article
Language:English
Published: American Society for Microbiology 2019-10-01
Series:mBio
Subjects:
yellow fever
attenuation
vaccine
ribavirin
quasispecies
live virus vaccine
Online Access:https://doi.org/10.1128/mBio.02294-19

Internet

https://doi.org/10.1128/mBio.02294-19

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