The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.

The interferon stimulated gene 20 protein (ISG20) is an innate defense antiviral factor that discriminates self versus non-self translation.

ISG20 is a broad spectrum antiviral protein thought to directly degrade viral RNA. However, this mechanism of inhibition remains controversial. Using the Vesicular Stomatitis Virus (VSV) as a model RNA virus, we show here that ISG20 interferes with viral replication by decreasing protein synthesis i...

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Bibliographic Details
Main Authors: Nannan Wu, Xuan-Nhi Nguyen, Li Wang, Romain Appourchaux, Chengfei Zhang, Baptiste Panthu, Henri Gruffat, Chloé Journo, Sandrine Alais, Juliang Qin, Na Zhang, Kevin Tartour, Frédéric Catez, Renaud Mahieux, Theophile Ohlmann, Mingyao Liu, Bing Du, Andrea Cimarelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-10-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008093

Internet

https://doi.org/10.1371/journal.ppat.1008093

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