Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum

Multimodal MRI analysis of basal forebrain structure and function across the Alzheimer’s disease spectrum

Background: Dysfunction of the cholinergic basal forebrain (cBF) is associated with cognitive decline in Alzheimer’s disease (AD). Multimodal MRI allows for the investigation of cBF changes in-vivo. In this study we assessed alterations in cBF functional connectivity (FC), mean diffusivity (MD), and...

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Main Authors: Meret Herdick, Martin Dyrba, Hans-Christian J. Fritz, Slawek Altenstein, Tommaso Ballarini, Frederic Brosseron, Katharina Buerger, Arda Can Cetindag, Peter Dechent, Laura Dobisch, Emrah Duezel, Birgit Ertl-Wagner, Klaus Fliessbach, Silka Dawn Freiesleben, Ingo Frommann, Wenzel Glanz, John Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Coraline D. Metzger, Matthias H. Munk, Oliver Peters, Josef Priller, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Maike Tscheuschler, Ruth Vukovich, Jens Wiltfang, Frank Jessen, Stefan Teipel, Michel J. Grothe
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:NeuroImage: Clinical
Subjects:
Cholinergic Basal Forebrain
Subjective Cognitive Decline
Alzheimer’s Disease
Functional Connectivity
Mean Diffusivity
Resting-state fMRI
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158220303326

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http://www.sciencedirect.com/science/article/pii/S2213158220303326

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