Modeling Membrane Morphological Change during Autophagosome Formation

Summary: Autophagy is an intracellular degradation process that is mediated by de novo formation of autophagosomes. Autophagosome formation involves dynamic morphological changes; a disk-shaped membrane cisterna grows, bends to become a cup-shaped structure, and finally develops into a spherical aut...

Full description

Bibliographic Details
Main Authors: Yuji Sakai, Ikuko Koyama-Honda, Masashi Tachikawa, Roland L. Knorr, Noboru Mizushima
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220306581